FIN56-induced ferroptosis is alleviated via supplementation with idebenone and selenite [186, 188]
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Glutathione is essential to neutralize free radicals, which are unstable molecules that result from the normal metabolic processes in the body
ERT is also potentially limited by reaccumulation of Gb3 in podocytes after dose adjustment during the follow-up period and formation of neutralizing antidrug antibodies after infusion, which reduce the efficacy of ERT by increasing cellular Gb3 deposition and results in harmful clinical outcomes that include progressive loss of renal function 13,14
This is a state where there is an imbalance between free radicalsunstable molecules that can damage cellsand the antioxidants that neutralize them